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Sr. Scientist, Antibody Discovery, Société CILOA

CILOA, a Biotech located in south of France, with a disruptive technology in the use of challenging proteins as immunogens is looking for an energetic Research Scientist with strong hands-on experience in immunology, cellular and molecular biology for a permanent position (CDI). Using state-of-the-art technologies, he will isolate antibody cDNA from single B cells. He will create a platform aiming to develop therapeutic antibodies. His success will contribute to our mission in the development of innovative therapeutics targeting so-called “undruggable” proteins involved in several types of pathologies.

Offered:

Opportunities to break new ground trusting you with responsibility early on and allowing you to fulfill your ambitions, and to draw your own career map that is responsive to your aspirations and priorities in life. Bring your imagination and skills to life!

Mission and key responsibilities:

  • Create and lead the platform of antibody generation using single B cell cloning strategy.

  • Design, execute and analyze experimental studies, propose creative solutions to troubleshoot problems, and proactively research new methods to improve processes.

  • Perform molecular and cellular biology experiments, including RT-PCR, PCR, recombinant DNA cloning, plasmid preps, bacterial transformation, mammalian cell culture, mammalian transfection for transient protein expression.

  • Conduct different assays: FACS, ELISA, Western blotting, BLI and SPR based Ab screening.

  • Collaborate and support other team members effectively to enhance productivity of the group and accomplish organizational goals.

  • Assist with process improvements by thinking critically about the design and execution of experiments, including automation, and SOP development.

  • With strong attention to detail, perform excellent record-keeping, time-management and organization to achieve group and company deliverables.

Required experience and skills:

  • Ph.D. in Molecular Biology, Immunology, or Cell Biology, with a minimum of 3+ years required; a post doc in relevant field a plus.

  • Experience in antibody generation strategies is desired; antibody engineering, optimization of effector function, affinity and biophysical properties a plus.

  • Experience with B cell biology with a solid background in mouse and human adaptive immune system, and in B/T cell differentiation.

  • Technical proficiency in molecular biology.

  • Mastery of sterile cell culture is a must.

  • Experience in multi-parameter/multi-color flow cytometry is desired. Knowledge of Flow cytometry based cell sorting is a plus.

  • Hands-on experience in antibody discovery methods, including advanced B-cell cloning is desired; hybridoma techniques, phage, yeast or/and mammalian display and other display technologies a plus.

  • Expertise in therapeutic antibody is desirable but not essential.

  • Familiarity with HTP automated recombinant protein expression is a plus.

  • Demonstrated ability to be proactive, diligent and reliable to meet deadlines. Excellent organization and planning skills.

  • Must be highly collaborative, team-oriented, yet with the ability to work independently.

  • Excellent interpersonal, verbal and written communication skills are required. Attention to detail and analytical.

  • Fluent English both written and verbal; French is a plus.

Applications should include: Send at contact(at)ciloa(dot)fr, a cover letter, CV, statement of research interests, and contact information for potential references.

Actualité

Deux dispositifs French Tech majeurs

Mars lève le voile sur deux dispositifs French Tech : "Le Next 40", "Le French Tech VISA"

N'hésitez pas à transmettre l'information à vos collègues startupper !


« Le Next 40 »,
annoncé lors du CES par Mounir Mahjoubi, secrétaire d'État chargé du Numérique, vise à mettre en avant sur la scène internationale 40 pépites en hyper-croissance et à "impact positif". Convaincu que de telles pépites se trouvent sur notre territoire, nous vous encourageons à candidater.
 lien pour postuler avant le 15 mars !!!

Conditions, remplir un de ces critères:

  • Lauréats Pass french tech 2018
  • Candidat Pass French tech 2019
  • Start-up ayant levé plus de 10M depuis 1er janvier 2018
  • Start-up ayant plus d'un million d'utilisateurs

 

« Le French Tech VISA », élargi à toutes les entreprises considérées comme innovantes. La V2 de ce VISA vise aussi et surtout à raccourcir les délais de traitement de près de 6 mois à quelques semaines !

Conditions, remplir un de ces critères:

  • avoir été bénéficiaire au cours des cinq dernières années d’un soutien public à l’innovation 
  • avoir une partie de son capital détenue par une entité ayant pour objet principal le financement ou l’investissement dans des entreprises innovantes 
  • avoir été accompagnée au cours des cinq dernières années par une structure d’accompagnement consacrée aux entreprises innovantes